To overcome and improve the traditional Bag In Bag Out procedure, which is used worldwide to couple drums in isolation technology applications, CSV Containment has designed and manufactured a Double Iris Interface (DIT®) system, an innovative device for drum handling, containment and automation. The DIT® system can be placed on both rigid and flexible isolators and consists of a cylindrical passage box with full-diameter opening and closing ends by means of an elastic elastomer diaphragm instead of folding doors. The double elastic barrier allows to minimize the contact surface of the drum with the internal atmosphere of the contaminated chamber and to automate the insertion and extraction operations. Furthermore, it is possible to obtain a negative or positive pressure difference between the double iris passage box and the adjacent chambers. Based on the DIT® technology, we have also created the Iris mouse hole pass through.